RESOURCES AND FAQ

Resources Pharmacy support Tips for caregivers Advocacy FAQs

RESOURCES ARE AVAILABLE

DOWNLOAD THESE INFORMATIVE GUIDES TO HELP YOU ON YOUR JOURNEY

HYRNUO patient brochure preview

PATIENT BROCHURE

Everything you need to know about HYRNUO®.

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HYRNUO side effects management guide preview

MANAGING SIDE EFFECTS

A useful guide to helping patients on HYRNUO manage possible side effects of treatment.

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HYRNUO patient support program guide preview

PATIENT SUPPORT PROGRAM OVERVIEW

More information on the financial assistance available to patients on HYRNUO.

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PERSONALIZED SUPPORT FROM SPECIALTY PHARMACIES

Onco360™ supports every step of your journey with HYRNUO

With dedicated specialty pharmacy, Onco360™, participating patients will receive:

  • One-on-one outreach from oncology-trained nurses and pharmacists to guide you through your first few weeks on treatment
  • Helpful tips and resources to manage potential side effects and stay on track with your care plan. For example, once prescribed HYRNUO you will receive a patient starter kit
  • Ongoing check-ins at key moments in your treatment journey, including reminders to fill your HYRNUO prescription
  • Clear guidance on how to take your medication, including dosing instructions and dietary considerations to help you get the most from your treatment
  • Insurance navigation and affordability options to help minimize out-of-pocket costs and ensure access to therapy

If you are receiving product through an in-office dispensing (IOD) pharmacy, you can reach out to your care team for additional support.

WHEN YOUR DOCTOR PRESCRIBES HYRNUO, ASK THEM ABOUT ONCO360™

TIPS FOR CAREGIVERS

Supporting someone through cancer is one of the hardest journeys. The physical and emotional demands can be exhausting, especially when each day brings new challenges. As you’re caring for your loved one, don’t forget that you need care, too.

  • Ask friends and family for help in caring for your loved one
  • Eat balanced meals and stay active to help reduce stress
  • Stay connected with friends and family by doing things you enjoy together

ADVOCACY GROUPS MAY PROVIDE ADDITIONAL SUPPORT

American Cancer Society logo

American Cancer Society

www.cancer.org
Longevity logo

LUNGevity

www.lungevity.org
GO2 For Lung Cancer logo

Go2 for Lung Cancer

www.go2.org
Cancer Support Community logo

Cancer Support Community

www.cancersupportcommunit
y.org
CancerCare logo

CancerCare

www.cancercare.org
Lung Cancer Research Foundation logo

Lung Cancer Research Foundation

www.lungcancerresearch
foundation.org

FREQUENTLY ASKED QUESTIONS ABOUT HYRNUO

ABOUT HER2-MUTATED NSCLC

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    What is NSCLC?

    Non-small cell lung cancer (NSCLC) is a form of cancer that develops in lung tissue. HER2 mutations have been identified in NSCLC.

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      What is HER2?

      Human epidermal growth factor receptor 2 (HER2) is a normal protein found in the body that signals for cells to grow. But when it mutates, it can lead to cancer cells growing in the body. The HER2 protein therefore essentially tells the cancer to grow.

      ABOUT HYRNUO

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        What is HYRNUO?

        HYRNUO is an oral tablet for the treatment of adults with non-squamous non-small cell lung cancer (NSCLC) that has spread within the chest (locally advanced) or to other parts of the body (metastatic) and has a certain abnormal HER2 gene(s).

        HYRNUO is approved under accelerated approval based on patient response data and duration of response. Studies are ongoing to confirm the clinical benefit of HYRNUO.

        HYRNUO is not chemotherapy. It is a targeted treatment, also known as a tyrosine kinase inhibitor (TKI).

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          How does HYRNUO work?

          HYRNUO works by targeting receptors on cells that signal growth, including cancer cells with mutated HER2. These mutations can lead to signals that promote uncontrolled and rapid growth of cancer cells. HYRNUO is designed to block these signals, which may help slow or stop the growth of cancer cells.

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            What were the results from the clinical study?

            In people using HYRNUO as their first treatment, 75% had a confirmed response to HYRNUO and those people (52 out of 69) had their response to treatment last between 1.5 months to 21.6 months and beyond. For full clinical trial results, visit the Results With HYRNUO page.

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              What are the most common side effects of HYRNUO?

              The most common side effects of HYRNUO are diarrhea, rash, nail problems including infection and inflammation, mouth sores, nausea, vomiting, and changes in certain blood tests.

              These are not all the possible side effects of HYRNUO. See full list of common and serious side effects.

              TAKING HYRNUO

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                How do I take HYRNUO and how often?

                HYRNUO is an oral tablet taken as two 10 mg tablets, twice a day, for a total of 40 mg. HYRNUO should be taken with food, once in the morning and once in the evening. Do not cut, crush, or chew tablets.

                Swallow the tablets whole. Your doctor may change your dose, temporarily stop, or completely stop your treatment with HYRNUO if you have certain side effects.

                If you vomit after taking a dose of HYRNUO, do not make up the dose. Take your next dose at your regularly scheduled time.

                GETTING HYRNUO

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                  Does HYRNUO offer financial support?

                  All patients new to HYRNUO can receive 1 month of free therapy through the HYRNUO Free Trial Program, regardless of insurance type or status.

                  Learn more about the free trial program.

                  HYRNUO offers personalized support regardless of your insurance coverage:

                  Commercially insured patients may be eligible for the HYRNUO $0 Co-Pay Program, where eligible patients may pay as little as $0.

                  Enroll now.

                  If you have Medicare or Medicaid, you may be eligible for government-funded programs such as Medicare Part D Extra Help, State Health Insurance Assistance Programs (SHIPs), and State Pharmaceutical Assistance Programs (SPAPs). Visit medicare.gov/basics/costs to check your eligibility.

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                    Can I access HYRNUO without insurance?

                    Support may be available for uninsured patients through the Bayer US Patient Assistance Foundation, a charitable organization that helps eligible patients get Bayer prescription medicine at no cost.

                    Visit www.patientassistance.bayer.us to see if you qualify for assistance, or call 1-866-228-7723 Monday-Friday 9:00 AM-6:00 PM (ET) for more information.

                    ELIGIBLE PATIENTS CAN PAY LESS FOR TREATMENT

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                    Important Safety Information

                    HYRNUO may cause serious side effects, including:

                    • diarrhea. Diarrhea can be severe during treatment with HYRNUO and usually occurs in the first week of treatment. Diarrhea can cause the loss of body fluids (dehydration) and salts (electrolyte imbalances). At the first signs of diarrhea (loose stool) or increased bowel movements, tell your healthcare provider right away, drink plenty of fluids, and start treatment for diarrhea as soon as possible. You should have an anti-diarrhea medicine available before you start treatment with HYRNUO.
                    • liver problems. HYRNUO may cause severe liver problems, including increases in liver blood tests. Your healthcare provider will do blood tests to check your liver function before you start and during treatment with HYRNUO. Tell your healthcare provider right away if you develop any signs and symptoms of liver problems, including:
                      • yellowing of the skin or white part of your eyes (jaundice)
                      • dark urine
                      • pale stools
                      • tiredness or weakness
                      • nausea or vomiting
                      • loss of appetite
                      • pain on the upper right side of your stomach
                    • lung problems. HYRNUO may cause severe lung problems. Tell your healthcare provider right away if you develop any new or worsening symptoms of lung problems during treatment with HYRNUO, including:
                      • cough
                      • fever
                      • shortness of breath or trouble breathing
                    • heart problems. HYRNUO may cause severe heart problems that may affect your heart’s ability to pump blood. Your healthcare provider will do tests to check your heart function before you start and during treatment with HYRNUO. Tell your healthcare provider right away if you develop any new or worsening signs or symptoms of heart problems, including:
                      • shortness of breath
                      • tiredness
                      • coughing
                      • irregular heartbeat
                      • swelling of your legs, ankles, or feet
                      • feeling dizzy or lightheaded
                      • loss of consciousness
                    • eye problems. HYRNUO can cause eye problems that can lead to temporary loss of vision. Tell your healthcare provider right away if you develop new or worsening signs or symptoms of eye problems. Your healthcare provider may send you to an eye specialist (ophthalmologist).
                    • pancreas problems. HYRNUO may cause increases in certain pancreatic blood tests (amylase and lipase). Your healthcare provider will do blood tests to check your pancreatic function during treatment with HYRNUO. Tell your healthcare provider right away if you develop any signs and symptoms of pancreas problems, including:
                      • upper stomach pain that may spread to your back and get worse with eating
                      • weight loss
                      • nausea or vomiting

                    Your healthcare provider may change your dose, temporarily stop, or completely stop your treatment with HYRNUO if you have certain side effects.

                    Before taking HYRNUO, tell your healthcare provider about all of your medical conditions, including if you:

                    • have liver problems.
                    • have lung or breathing problems other than lung cancer.
                    • have heart problems.
                    • have vision or eye problems.
                    • are pregnant or plan to become pregnant. HYRNUO can harm your unborn baby.
                      • Females who are able to become pregnant:
                      • Your healthcare provider will do a pregnancy test before you start treatment with HYRNUO.
                      • Use effective birth control (contraception) during treatment and for 1 week after the last dose of HYRNUO.
                      • Talk to your healthcare provider about birth control methods that may be right for you.
                      • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during your treatment with HYRNUO.
                      • Males with female partners who are able to become pregnant:
                      • Use effective birth control (contraception) during treatment and for 1 week after your last dose of HYRNUO.
                      • Talk to your healthcare provider about birth control methods that may be right for you and your partner.
                    • are breastfeeding or plan to breastfeed. It is not known if HYRNUO passes into breast milk. Do not breastfeed during treatment and for 1 week after the last dose of HYRNUO.

                    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. HYRNUO may affect the way other medicines work, and other medicines may affect how HYRNUO works.

                    Know the medicines you take. Keep a list of them with you to show to your healthcare provider and pharmacist when you get a new medicine.

                    The most common side effects of HYRNUO include:

                    • diarrhea
                    • rash
                    • nail problems, including infection and inflammation
                    • mouth sores
                    • nausea
                    • vomiting
                    • changes in certain blood tests

                    These are not all of the possible side effects of HYRNUO.

                    Call your doctor for medical advice about side effects. You may report side effects to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088.

                    Please see full Prescribing Information. 

                    What is HYRNUO?

                    HYRNUO is a prescription medicine used to treat adults with a type of lung cancer called non-squamous non-small cell lung cancer (NSCLC) that:

                    • has spread within the chest (locally advanced) or to other parts of the body (metastatic), and
                    • has a certain abnormal human epidermal growth factor receptor 2 (HER2) gene(s).

                    Your healthcare provider will perform a test to make sure HYRNUO is right for you.

                    It is not known if HYRNUO is safe and effective in children.

                    Site last modified 09/2026

                    © 2026 Bayer. All rights reserved. BAYER, the Bayer Cross and HYRNUO are registered trademarks of Bayer.

                    You are encouraged to report side effects or quality complaints of products to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. 

                    For Bayer products, you can report these directly to Bayer by clicking here. 

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